The AISAC Mod trigger is activated by REACT. This trigger is one-shot but its effect stays active.
Therefore, subsequent playbacks are affected, unless you create a curve which restores the changes caused by the AISAC.

For example, if you use the following setting to lower the pitch, it will not return to the original pitch afterwards.

It is recommended to change the AISAC using a ducker if a change occurs from activating/stopping REACT.
In this case, it will go back to the original value when the AISAC control value is changed.